Aptamer Optimer®

Aptamer Group plc, the developer of next-generation synthetic binders for the lifesciences industry, is pleased to announce that Twist Bioscience Corporation has launched its newTrueAmp Library Preparation Kit, which uses Aptamer's proprietary Optimer® binders as an enablingtechnology for stability at room temperature, within the TrueAmp Library Preparation Kit¹.Product LaunchThe TrueAmp Library Preparation Kit represents a significant advancement in next-generationsequencing (NGS) library amplification workflows. By using Aptamer's Optimer® binders, the TwistTrueAmp Library Prep Kit delivers a new level of exceptional performance to Twist’s library preparationportfolio. These advantages are enabled by Twist’s in-house developed enzymes, including a previouslydeveloped ligase and a newly developed polymerase.Engineered for NGS applications, the specialised TrueAmp polymerase maximises coverage acrosstypically hard-to-sequence regions of the genome - while maintaining high accuracy during DNAcopying.

The kit delivers high yields even from low-input or degraded starting samples, whichminimises amplification-introduced errors and results in more usable high-quality data. To streamlinelarge-scale workflows, the Twist TrueAmp Library Prep Kit has been validated with the Twist HT-UDIadapter system, allowing for up to 3,072 unique indexes as well as Twist UMI adapters, ensuringprecise strand identification and efficient multiplexing.Partnership BackgroundAs announced in December 2025,2 Aptamer issued a non-exclusive license to Twist Bioscience for theuse of the Optimer inhibitor for a proprietary high-fidelity polymerase.This partnership strategically combines Twist Bioscience's expertise in synthetic biology and genomicswith Aptamer's pioneering Optimer® binder technology to create solutions for the rapidly expandingnext-generation sequencing market.Dr Arron Tolley, Chief Executive Officer of Aptamer Group, commented: “We are delighted to play asmall but significant part in Twist Bioscience bringing the TrueAmp Library Preparation Kit to market.This product launch demonstrates the real-world value of our Optimer® technology in enablingmarket-ready products.In this hot-start PCR application, the Optimer® binder demonstrates robust performance, eliminatingthe need for two separate antibody reagents typically required in alternative methods. We look forward to the continued success of our collaboration with Twist Bioscience and the transformativeimpact this product will have in advancing genomics research and clinical applications.”